Q. Is it true that farmers are more likely to get Parkinson's disease? A: Although genetics is very important in Parkinson's disease, many researchers believe that environmental exposures also increase a person's risk of developing the disease. There are studies that show that farmers and other agricultural workers have an increased risk of getting Parkinson's. Parkinson's was first described in 1817 by Dr. James Parkinson, a British physician. It affects one in 100 people older than 60. It can also affect younger people. The average age of onset is 60. Research suggests that Parkinson's affects at least 500,000 people in the United States. Parkinson's is a complex disorder of the central nervous system. It is the second most common neurodegenerative disease in the United States, after Alzheimer's. The defining symptoms of Parkinson's include tremor, slowness of movement, rigidity and impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking or completing simple tasks. They also may experience depression, difficulty sleeping and other problems. The progression of symptoms in Parkinson's may take 20 years or more. In some people, however, the disease progresses much more quickly. In the early 1960s, scientists determined that the loss of brain cells was causing Parkinson's. The cells that were depleted produced dopamine, a chemical that helps control muscle activity. Today, Parkinson's is treated with drugs and surgery. Medications for Parkinson's fall into three categories. The first includes drugs that increase the level of dopamine in the brain. The second category affects neurotransmitters in the body to ease some of the symptoms of the disease. The third category includes medications that help control the non-motor symptoms of the disease, such as depression. There are two commonly used surgical treatments for Parkinson's: pallidotomy and deep brain stimulation. Because these procedures are invasive, they are usually reserved for severely afflicted Parkinson's patients who do not get adequate relief from medications. Surgeons discovered that by removing or destroying parts of the brain that were "misfiring," some of the symptoms of Parkinson's could be alleviated. One of these operations is pallidotomy. Scientists have found that they can mimic the effects of pallidotomy by deep brain stimulation. With this treatment, an electrode is implanted in the brain in a way that calms the abnormal neuronal firing. Deep brain stimulation is now the primary surgical intervention for Parkinson's. A wide variety of complementary and supportive therapies may be used for Parkinson's. Among these therapies are standard rehabilitation techniques, which can help with problems such as gait and voice disorders, tremors and rigidity, and cognitive decline. Exercise may help people improve their mobility. While Parkinson's is a complex disease, research has progressed a great deal in recent years. Halting the progression of Parkinson's, restoring lost function and even preventing the disease are now considered realistic goals. -- If you have a question, please write to [firstname.lastname@example.org](mailto:email@example.com) All Rights Reserved © 2008 by Fred Cicetti
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